Calculate Your CardioMetAge
Enter the 12 biomarkers from your blood test below. All fields are required for an accurate CardioMetAge estimate.
The Science Behind CardioMetAge
What is CardioMetAge?
CardioMetAge is a cardiometabolic biological age clock published in BMC Medicine (2026) by researchers at Fudan University. Your chronological age counts years since birth. CardioMetAge estimates how old your cardiovascular and metabolic system actually appears based on 12 objective biomarkers from a standard blood test. This calculator lets you compute your own score instantly.
How was the formula developed?
The CardioMetAge formula was trained on 13,262 participants from the NHANES-III study, then independently validated on 31,745 (NHANES) and 418,118 (UK Biobank) individuals—463,125 people in total. It uses a Gompertz mortality model specifically calibrated for deaths from heart disease, stroke, and diabetes.
Why does your CardioMetAge matter?
- Each 3.7-year increase in CardioMetAge deviation was associated with an 87% higher risk of cardiometabolic death
- CardioMetAge predicted heart disease, stroke, diabetes, and kidney disease more accurately than previous biological age models
- Diet and physical activity explained about 33% of the lifestyle-related risk captured by the score
- In a clinical trial, two years of caloric restriction slowed CardioMetAge progression by 1.23 years
Can you lower your CardioMetAge?
Yes. Every biomarker in the CardioMetAge formula is influenced by modifiable lifestyle factors—diet, exercise, weight management, and stress reduction. The research demonstrated that caloric restriction, diet quality, and physical activity all meaningfully reduce your score. Use this calculator over time to track your progress.
The 12 Biomarkers in CardioMetAge
CardioMetAge Biomarker Reference
The CardioMetAge calculator uses 12 biomarkers from a standard blood panel (CBC + CMP). Each one contributes to your cardiometabolic biological age. Expand any biomarker below to learn what it measures, what influences it, and whether higher values make you appear older or younger.
HbA1c% · Higher → older
Average blood sugar over 2-3 months.
Key influences: Diet (refined carbs, sugar), exercise, weight, genetics.
Normal range: 3–18 % · Reference value: 5.5 %
Red Cell Distribution Width (RDW)% · Higher → older
Variation in red blood cell size.
Key influences: Iron/B12/folate status, inflammation, bone marrow health.
Normal range: 9–25 % · Reference value: 12.9 %
Systolic Blood PressuremmHg · Higher → older
Force of blood against artery walls during heartbeat.
Key influences: Sodium intake, exercise, weight, stress, medications.
Normal range: 70–250 mmHg · Reference value: 124 mmHg
Creatininemg/dL · Higher → older
Kidney filtration efficiency.
Key influences: Kidney health, hydration, muscle mass, protein intake.
Normal range: 0.1–15 mg/dL · Reference value: 0.9 mg/dL
Lymphocyte Percentage% · Higher → younger
Proportion of immune cells that are lymphocytes.
Key influences: Immune function, infections, stress, exercise.
Normal range: 2–70 % · Reference value: 30 %
Mean Corpuscular Volume (MCV)fL · Higher → older
Average size of red blood cells.
Key influences: B12/folate levels, iron status, alcohol intake, thyroid.
Normal range: 50–130 fL · Reference value: 89.5 fL
Resting Pulse Ratebpm · Higher → older
Heart beats per minute at rest.
Key influences: Fitness level, stress, caffeine, medications, sleep.
Normal range: 30–200 bpm · Reference value: 73 bpm
Pulse PressuremmHg · Higher → older
Difference between systolic and diastolic pressure.
Key influences: Arterial stiffness, age, exercise, sodium.
Normal range: 10–150 mmHg · Reference value: 46 mmHg
Uric Acidmg/dL · Higher → older
Waste product from purine metabolism.
Key influences: Diet (red meat, seafood, alcohol), kidney function, genetics.
Normal range: 0.5–15 mg/dL · Reference value: 5.3 mg/dL
C-Reactive Protein (CRP)mg/dL · Higher → older
General inflammation marker.
Key influences: Infections, chronic inflammation, obesity, smoking, diet.
Normal range: 0.01–30 mg/dL · Reference value: 0.35 mg/dL
Waist Circumferencecm · Higher → older
Abdominal fat distribution.
Key influences: Diet, exercise, body composition, hormones.
Normal range: 50–200 cm · Reference value: 96 cm
Blood Urea Nitrogen (BUN)mg/dL · Higher → older
Waste product from protein metabolism.
Key influences: Kidney function, hydration, protein intake.
Normal range: 2–80 mg/dL · Reference value: 13.5 mg/dL